The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase.

Joanna BrühlJonathan TrautweinAgnes SchäferUwe LinneKarim Bouazoune

Published in: Epigenetics & chromatin (2019)

We propose that, in addition to polyubiquitinating PCNA, SHPRH promotes DNA repair or transcriptional regulation in part through chromatin ubiquitination. Our study sets a biochemical framework for studying other RAD5- and RAD16-related protein functions through the ubiquitination of nucleosomes.

Keyphrases

dna repair
dna damage
dna damage response
gene expression
oxidative stress
transcription factor
protein protein