Metabolomic Profile of BALB/c Macrophages Infected with Leishmania amazonensis: Deciphering L-Arginine Metabolism.

Sandra Marcia MuxelMaricruz Mamani-HuancaJuliana Ide AokiRicardo Andrade ZampieriLucile Maria Floeter-WinterÁngeles López-Gonzálvez Coral Barbas

Published in: International journal of molecular sciences (2019)

The metabolome fingerprint indicated that Leishmania infection alters the L-arginine/polyamines/trypanothione metabolism inside the host cell and the parasite arginase impacts on L-arginine metabolism and polyamine production, defining the infection fate.

Keyphrases

nitric oxide
amino acid
nitric oxide synthase
single cell
cell therapy
stem cells