Cost-effective 3D lung tissue spheroid as a model for SARS-CoV-2 infection and drug screening.

Guilherme A S C MirandaIsadora Alonso CorrêaÉrica Almeida AmorimLucio Ayres CaldasFabiana Ávila CarneiroLuciana Jesus da CostaJosé Mauro GranjeiroAmilcar TanuriWanderley de SouzaLeandra Santos Baptista

Published in: Artificial organs (2024)

This study demonstrates that coculture spheroids of epithelial and stromal cells can serve as a cost-effective infection model for the SARS-CoV-2 virus. We suggest using this 3D spheroid as a drug screening platform to explore new treatments related to the cytokines released during virus infection, especially for long COVID treatment.

Keyphrases

sars cov
respiratory syndrome coronavirus
coronavirus disease
adverse drug
drug induced
emergency department
smoking cessation