Functional Localization of Adult-Onset Idiopathic Nesidioblastosis.
Jess C HercusPouneh PashaSadiq Al LawatiPeter KimAndre MattmanDouglas WebberDavid M ThompsonPublished in: Case reports in endocrinology (2022)
Nesidioblastosis is a rare pancreatic disorder involving enlarged beta cells throughout the pancreas, causing elevated insulin production. We present the case of a 53-year-old woman with the initial symptom of fasting hypoglycemia. No pancreatic lesions were indicated on computed tomography and magnetic resonance imaging scans, and an octreotide scan was negative for insulinoma. Selective arterial calcium stimulation (SACST) showed increased insulin production from the stimulation of 3 out of 5 arteries. The SACST results suggested a diagnosis of nesidioblastosis, which was confirmed by histopathology after a subtotal distal pancreatectomy. The patient has normal glucose tolerance after surgery with no further problems of hypoglycemia, indicating that this is a rare case of nesidioblastosis extending only partially through the pancreas.
Keyphrases
- computed tomography
- type diabetes
- rare case
- glycemic control
- magnetic resonance imaging
- blood glucose
- positron emission tomography
- contrast enhanced
- induced apoptosis
- insulin resistance
- dual energy
- cell cycle arrest
- mental health
- case report
- image quality
- minimally invasive
- cell death
- weight loss
- endoplasmic reticulum stress
- oxidative stress
- signaling pathway
- cell proliferation
- magnetic resonance
- metabolic syndrome
- blood pressure
- neuroendocrine tumors
- pet ct