The protein arginine methyltransferase PRMT5 confers therapeutic resistance to mTOR inhibition in glioblastoma.

Brent HolmesAngelica Benavides-SerratoJacquelyn T SaundersKenna A LandonAdam J SchreckRobert N NishimuraJoseph F Gera

Published in: Journal of neuro-oncology (2019)

These results demonstrate that PRMT5 activity is stimulated upon mTOR inhibition in GBM. Our data further support a signaling cascade in which PRMT5-mediated methylation of hnRNP A1 promotes IRES RNA binding and activation of IRES-mediated protein synthesis and resultant mTOR inhibitor resistance.

Keyphrases

cell proliferation
nitric oxide
amino acid
binding protein
electronic health record
genome wide
protein protein
small molecule
machine learning
deep learning
data analysis