Species-specific optimization of PEG~SN-38 prodrug pharmacokinetics and antitumor effects in a triple-negative BRCA1-deficient xenograft.

Shaun D FontaineByron HannRalph ReidGary W AshleyDaniel V Santi

Published in: Cancer chemotherapy and pharmacology (2019)

The efficacy of a macromolecular prodrug can be optimized for a given species by balancing the rate of drug release from the carrier with the rate of prodrug elimination.

Keyphrases

cancer therapy
drug release
drug delivery
emergency department
genetic diversity
wild type