A Modified Murine Calvarial Osteolysis Model Exposed to Ti Particles in Aseptic Loosening.
Zhantao DengShuai WangMengyuan LiGuangtao FuChang LiuShuxian LiJiewen JinFeng-Juan LyuYuanchen MaQiujian ZhengPublished in: BioMed research international (2020)
A mouse calvarial model is the most effective animal model for the primary in vivo research of aseptic loosening. Compared with commercial Ti particles, TiAl6V4 particles derived from prosthesis of an aseptic loosening patient had more severe bone loss and more activated osteoclast, which was more consistent with pathogenesis of aseptic loosening in vivo, had high success rate of establishment of a model, and was more desired in animal modeling.