Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation.

Elizabeth L EvansKevin CuthbertsonNaima EndeshBaptiste RodeNicola M BlytheAdam J HymanSally J HallHannah J GauntMelanie J LudlowRichard FosterDavid J Beech

Published in: British journal of pharmacology (2018)

Chemical antagonism of Yoda1-evoked Piezo1 channel activity is possible, and the existence of a specific chemical interaction site is suggested with distinct binding and efficacy domains.

Keyphrases

aortic valve
left ventricular
heart failure
aortic dissection
coronary artery
atrial fibrillation
transcription factor
pulmonary hypertension
pulmonary arterial hypertension