Multimodality Imaging and Biomarker Approach to Characterize the Pathophysiology of Heart Failure in Left Ventricular Non-Compaction with Preserved Ejection Fraction.
Ionela Simona VișoiuRoxana Cristina RimbasAlina Ioana NiculaSorina Mihaila-BaldeaStefania Lucia MagdaDiana Janina MihalceaMemis HayatMaria Luiza LuchianAlexandra Maria ChitroceanuDragos VinereanuPublished in: Journal of clinical medicine (2023)
LVNC patients with HFpEF have diffuse fibrosis, which is more extensive at the apical level, explaining the decrease in apical deformation and overexpression of Galectin-3. Lower transmural and base-to-apex deformation gradients underpin the sequence of myocardial maturation failure. Endothelial dysfunction, expressed by the lower ADAMTS13 and ADAMTS13/vWF ratio, may play an important role in the mechanism of HFpEF in patients with LVNC.
Keyphrases
- ejection fraction
- left ventricular
- aortic stenosis
- heart failure
- cardiac resynchronization therapy
- hypertrophic cardiomyopathy
- high resolution
- acute myocardial infarction
- left atrial
- transcatheter aortic valve replacement
- mitral valve
- cell proliferation
- transcription factor
- low grade
- atrial fibrillation
- acute coronary syndrome
- acute heart failure
- amino acid
- aortic valve
- high grade
- liver fibrosis