Mitochondrial oxidative phosphorylation in peripheral blood mononuclear cells is decreased in chronic HIV and correlates with immune dysregulation.

Louie Mar A GangcuangcoBrooks I MitchellChathura SiriwardhanaLindsay B KohornGlen M ChewScott BowlerKalpana J KallianpurDominic C ChowLishomwa C NdhlovuMariana GerschensonCecilia M Shikuma

Published in: PloS one (2020)

CI PBMC protein levels were decreased in PLWH on ART. Decreased OXPHOS correlated with disease severity and inflammation. Further studies on the relationship between immunometabolism and immune dysregulation in HIV are warranted.

Keyphrases

antiretroviral therapy
hiv infected
hiv positive
human immunodeficiency virus
hiv testing
oxidative stress
hiv aids
hepatitis c virus
men who have sex with men
protein protein
small molecule
amino acid
case control