Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas.

Ayako Nakashoji Naoki Haratake Atrayee Bhattacharya Weipu Mao Kangjie Xu Keyi Wang Tatsuaki Daimon Hiroki Ozawa Kazuhiro Matsumoto Atsushi Fushimi Nami Yamashita Yoshihiro Morimoto Mototsugu Shimokawa Shin Saito Ann Marie Egloff Ravindra Uppaluri Mark D Long Donald W Kufe

Published in: Cancer research communications (2024)

This work reports a previously unrecognized role for MUC1-C in driving STAT1-mediated chronic inflammation with the progression of HNSCC and identifies MUC1-C as a druggable target for advanced HNSCC treatment.

Keyphrases

squamous cell
oxidative stress
cell proliferation
signaling pathway
adverse drug
gene expression
combination therapy