Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis.

Andrew M McIntoshLynsey S HallYanni ZengMark James Adams Jude Gibson Eleanor M Wigmore Saskia P HagenaarsGail DaviesAna Maria Fernandez-Pujals Archie I CampbellToni-Kim ClarkeCaroline HaywardChris S HaleyDavid J PorteousIan J DearyDaniel J SmithBarbara I NichollDavid A HindsAmy V JonesSerena ScollenWeihua MengBlair Hamilton SmithLynne J Hocking

Published in: PLoS medicine (2016)

Genetic factors, as well as chronic pain in a partner or spouse, contribute substantially to the risk of chronic pain for an individual. Chronic pain is genetically correlated with MDD, has a polygenic architecture, and is associated with polygenic risk of MDD.

Keyphrases

chronic pain
major depressive disorder
bipolar disorder
pain management
copy number
genome wide
risk assessment
gene expression
hepatitis c virus
human health
hiv infected
life cycle