Divergent Adaptations in Autonomic Nerve Activity and Neuroimmune Signaling Associated With the Severity of Inflammation in Chronic Colitis.

Rhian StavelyAhmed A RahmanLauren SahakianMonica D PrakashAinsley M RobinsonMajid HassanzadeganroudsariRhiannon T FilipponeSarah FraserRajaraman EriJoel C BornsteinVasso Apostolopoulos Kulmira Nurgali

Published in: Inflammatory bowel diseases (2022)

Sympathetic activity may correlate with an adaptive mechanism to reduce the severity of chronic colitis. The Winnie and Winnie-Prolapse mouse models of moderate and severe chronic colitis are well suited to examine the pathophysiology of progressive chronic intestinal inflammation.

Keyphrases

oxidative stress
mouse model
early onset
heart rate