Identification of novel biomarkers of hepatocellular carcinoma by high-definition mass spectrometry: Ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry and desorption electrospray ionization mass spectrometry imaging.
Koshi NagaiBaasanjav UranbilegZhen ChenAmane FujiokaTakahiro YamazakiYotaro MatsumotoHiroki TsukamotoHitoshi IkedaYutaka YatomiHitoshi ChibaShu-Ping HuiToru NakazawaRitsumi SaitoSeizo KoshibaJunken AokiDaisuke SaigusaYoshihisa TomiokaPublished in: Rapid communications in mass spectrometry : RCM (2019)
Novel biomarkers for HCC were identified by a comprehensive and reproducible G-Met method with HDMS using a mixed-mode column. The combination analysis of UHPLC/QTOFMS and DESI-MSI revealed that the different molecular species of TGs were associated with tumor distribution and were useful for characterizing the progression of tumor cells and discovering prospective biomarkers.
Keyphrases
- liquid chromatography
- mass spectrometry
- high resolution mass spectrometry
- tandem mass spectrometry
- simultaneous determination
- ultra high performance liquid chromatography
- high performance liquid chromatography
- solid phase extraction
- high resolution
- gas chromatography
- ms ms
- capillary electrophoresis
- single cell
- tyrosine kinase
- bioinformatics analysis
- genetic diversity