β1-Blocker improves survival and ventricular remodelling in rats with lethal crush injury.

Mengyang YuQi LvJie ShiYahua LiuHaojun FanHui DingZiquan LiuJuan CaoYanhua GongShike Hou

Published in: European journal of trauma and emergency surgery : official publication of the European Trauma Society (2020)

Our findings demonstrated the presence of myocardial injury in the early stage of compression in rats with a crush injury. Pretreatment with a β1-blocker (bisoprolol) with fluid resuscitation significantly reduced mortality, decreased myocardial tissue damage, and improved ventricular remodelling in rats with a lethal crush injury.

Keyphrases

early stage
left ventricular
heart failure
optic nerve
cardiac arrest
oxidative stress
cardiovascular disease
squamous cell carcinoma
cardiovascular events
type diabetes
coronary artery disease
catheter ablation
risk factors
lymph node
cardiopulmonary resuscitation
neoadjuvant chemotherapy