Transcriptome profiling of Staphylococci-infected cow mammary gland parenchyma.
Ewa M KosciuczukPaweł LisowskiJustyna JarczakAlicja MajewskaMagdalena RzewuskaLech ZwierzchowskiEmilia BagnickaPublished in: BMC veterinary research (2017)
A coagulase-positive Staphylococci infection caused a markedly stronger host response than that of coagulase-negative, resulting in vastly increased DEGs. A significant increase in the expression of the FOS, TNF, and genes encoding the major histocompatibility complex proteins (MHC) was observed. It suggests these genes play a key role in the synchronization of the immune response of the cow's parenchyma against mastitis-causing bacteria. Moreover, the following genes that belong to several physiological pathways (KEGG pathways) were selected for further studies as candidate genes of mammary gland immune response for use in Marker Assisted Selection (MAS): chemokine signaling pathway (CCL2, CXCL5, HCK, CCR1), cell adhesion molecules (CAMs) pathway (BOLA-DQA2, BOLA-DQA1, F11R, ITGAL, CD86), antigen processing and presentation pathway (CD8A, PDIA3, LGMN, IFI30, HSPA1A), and NOD-like receptor signaling pathway (TNF, IL8, IL18, NFKBIA).
Keyphrases
- immune response
- signaling pathway
- genome wide
- cell adhesion
- rheumatoid arthritis
- bioinformatics analysis
- dendritic cells
- genome wide identification
- pi k akt
- epithelial mesenchymal transition
- single cell
- dna methylation
- gene expression
- genome wide analysis
- binding protein
- toll like receptor
- rna seq
- induced apoptosis
- inflammatory response
- transcription factor
- endoplasmic reticulum stress
- oxidative stress
- long non coding rna
- cell proliferation
- innate immune