Optimising the dose of clonidine to achieve sedation in intensive care unit patients with population pharmacokinetics.
Michael E CloesmeijerHuub L A van den OeverRon A A MathôtMarieke ZeemanArriette Kruisdijk-GerritsenCarmen M A BlesPolina NassikovkerArthur R de MeijerFred L van SteveninckMaurits E L ArbouwPublished in: British journal of clinical pharmacology (2020)
A population PK model for clonidine was developed in an adult ICU. A dosing regimen of 1200 μg/d provided a target sedation concentration of >1.5 μg/L.