Limited value of testing for factor XIII and α2-antiplasmin deficiency in patients with a bleeding disorder of unknown cause.

Sander AriënsAlbert HuismanIdske C L Kremer HovingaRolf T UrbanusKarin P M van Galen Lize F D van Vulpen Kathelijn Fischer Roger E G Schutgens

Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2024)

In our cohort of BDUC patients, no clinical relevant FXIII deficiencies were detected; absolute values were well above the 30% cutoff considered adequate for normal haemostasis. No α2AP deficiencies were detected. These data suggest that in BDUC patients, measuring FXIII or AP activity is of limited value.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
transcription factor
big data
patient reported
replacement therapy