Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial.

Stefan HagelFriedhelm BachThorsten BrennerHendrik BrachtAlexander BrinkmannThorsten AnneckeAndreas HohnMarkus WeigandGuido MichelsStefan KlugeAxel NierhausDominik JarczakChristina KönigDirk WeismannOtto FreyDominic WitzkeCarsten MüllerMichael BauerMichael KiehntopfSophie NeugebauerThomas LehmannJason A RobertsMathias W Pletznull null

Published in: Intensive care medicine (2022)

TDM-guided therapy showed no beneficial effect in patients with sepsis and continuous infusion of piperacillin/tazobactam with regard to the mean SOFA score. Larger studies with strategies to ensure optimization of antimicrobial exposure are needed to definitively answer the question.

Keyphrases

septic shock
acute kidney injury
intensive care unit
staphylococcus aureus
gram negative
multidrug resistant
mesenchymal stem cells
bone marrow
drug induced