Optimizing myocardial cell protection with xanthine derivative KMUP-3 potentiates autophagy through the PI3K/Akt/eNOS axis.

Shang-En HuangJong-Hau HsuBo-Wen ShiauYi-Ching LiuBin-Nan WuZen-Kong DaiChung-Pin LiuJwu-Lai Yeh

Published in: Basic & clinical pharmacology & toxicology (2024)

These findings enable the core pathway of PI3K/Akt/eNOS axis in KMUP-3-enhanced autophagy activation and suggest its principal role in safeguarding against cardiotoxicity.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
cell death
endoplasmic reticulum stress
cell proliferation
left ventricular
uric acid
metabolic syndrome
water soluble
endothelial cells
nitric oxide