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Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin-O-glucuronide in HeLa1A1 cells.

Yang LiChunxia XuJinjin XuZifei QinShishi LiLiufang HuZhi-Hong YaoFrank J GonzalezXinsheng Yao
Published in: The Journal of pharmacy and pharmacology (2020)
CYP1A1 and CYP2C9, UGT1A1, UGT1A7, UGT1A8 and UGT1A9, and MRP4 all played important roles in the metabolism and disposition of bavachin.
Keyphrases
  • cell cycle arrest
  • induced apoptosis
  • cell death
  • endoplasmic reticulum stress
  • oxidative stress