PFTK1 kinase regulates axogenesis during development via RhoA activation.
Yasmilde Rodríguez GonzálezFatemeh KamkarPaymaan Jafar-NejadSuzi WangDianbo QuLeticia Sanchez AlvarezDina HawariMargaret SonnenfeldRuth S SlackPaul R AlbertDavid S ParkAlvin JoselinPublished in: BMC biology (2023)
In conclusion, our work establishes an unreported neuronal role of PFTK1 in axon development mediated by phosphorylation and activation of GDP-bound RhoA. The results presented add to our understanding of the role of Cdks in the maintenance of RhoA-mediated axon growth and its impact on CNS development and axonal regeneration.