IFN-γ enhances the efficacy of mesenchymal stromal cell-derived exosomes via miR-21 in myocardial infarction rats.

Jian ZhangYao LuYangming MaoYue YuTianyu WuWei ZhaoYeqian ZhuPengcheng ZhaoFeng-Xiang Zhang

Published in: Stem cell research & therapy (2022)

IFN-γ-Exo showed enhanced therapeutic efficacy against acute MI, possibly by promoting angiogenesis and reducing apoptosis by upregulating miR-21, which directly targeted BTG2.

Keyphrases

cell proliferation
long non coding rna
bone marrow
long noncoding rna
stem cells
immune response
dendritic cells
mesenchymal stem cells
liver failure
oxidative stress
heart failure
endoplasmic reticulum stress
cell death
respiratory failure
cancer therapy
atrial fibrillation