A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis.
null nullDavid R FlumGiana H DavidsonSarah E MonsellNathan I ShapiroStephen R OdomSabrina E SanchezF Thurston DrakeKatherine FischkoffJeffrey JohnsonJoe H PattonHeather EvansJoseph CuschieriAmber K SabbatiniBrett A FaineDionne A SkeeteMike K LiangVance SohnKaren McGraneMatthew E KutcherBruce ChungDamien W CarterPatricia Ayoung-CheeWilliam ChiangAmy RushingSteven SteinbergCareen S FosterShaina M SchaetzelThea P PriceKatherine A MandellLisa FerrignoMatthew SalzbergDaniel A DeUgarteAmy H KajiGregory J MoranDarin SaltzmanHasan B AlamPauline K ParkLillian S KaoCallie M ThompsonWesley H SelfJulianna T YuAbigail WiebuschRobert J WinchellSunday ClarkAnusha KrishnadasanErin FannonDanielle C LavalleeBryan A ComstockBonnie BizzellPatrick J HeagertyLarry G KesslerDavid A TalanPublished in: The New England journal of medicine (2020)
For the treatment of appendicitis, antibiotics were noninferior to appendectomy on the basis of results of a standard health-status measure. In the antibiotics group, nearly 3 in 10 participants had undergone appendectomy by 90 days. Participants with an appendicolith were at a higher risk for appendectomy and for complications than those without an appendicolith. (Funded by the Patient-Centered Outcomes Research Institute; CODA ClinicalTrials.gov number, NCT02800785.).