Ultra-high frequency repetitive TMS at subthreshold intensity induces suprathreshold motor response via temporal summation.
Andrew-Hieu NguyenCharlotte Qiong LiSamantha HoffmanZhi-De DengYihong YangHanbing LuPublished in: Journal of neural engineering (2024)
We propose that the temporal summation effect can be leveraged to design the next-generation focal TMS system: by sequentially driving multiple coils at high-frequency and subthreshold intensity, areas with the most significant overlapping E-fields undergo maximal temporal summation effects, resulting in a suprathreshold response.