TAK-242 (Resatorvid) inhibits proinflammatory cytokine production through the inhibition of NF-κB signaling pathway in fibroblast-like synoviocytes in osteoarthritis patients.
Mohammadreza Khomeijani-FarahaniJafar KaramiElham FarhadiSamaneh SoltaniAli-Akbar DelbandiMehdi ShekarabiMohammad Naghi TahmasebiArash Sharafat VaziriAhmadreza JamshidiMahdi MahmoudiMasoomeh AkhlaghiPublished in: Advances in rheumatology (London, England) (2024)
According to our results, TAK-242 shows promising inhibitory effects on TLR4-mediated inflammatory responses in OA-FLSs by targeting the NF-κB pathway. TLR4 inhibitors, such as TAK-242, may be useful therapeutic agents to reduce inflammation and its associated complications in OA patients, since traditional and biological treatments may not be adequate for all of them.
Keyphrases
- signaling pathway
- end stage renal disease
- newly diagnosed
- ejection fraction
- oxidative stress
- chronic kidney disease
- pi k akt
- inflammatory response
- immune response
- peritoneal dialysis
- toll like receptor
- lps induced
- nuclear factor
- knee osteoarthritis
- risk factors
- patient reported outcomes
- cell proliferation
- induced apoptosis