X-ray multiscale 3D neuroimaging to quantify cellular aging and neurodegeneration postmortem in a model of Alzheimer's disease.
Giacomo E BarboneAlberto BravinAlberto MittoneAlexandra PacureanuGiada MascioPaola Di PietroMarkus J KraigerMarina EckermannMariele RomanoMartin Hrabě de AngelisPeter CloetensValeria BrunoGiuseppe BattagliaPaola CoanPublished in: European journal of nuclear medicine and molecular imaging (2022)
This multiscale micro-to-nano 3D imaging method based on X-PCI-CT enabled identification and quantification of cellular and sub-cellular aging and neurodegeneration in deep neuronal and glial cell populations in a transgenic model of Alzheimer's disease. This approach quantified the localized and intracellular neuroprotective effects of pharmacological activation of mGlu2/3 receptors.
Keyphrases
- high resolution
- dual energy
- cognitive decline
- computed tomography
- coronary artery disease
- cerebral ischemia
- single cell
- acute myocardial infarction
- image quality
- atrial fibrillation
- cell therapy
- heart failure
- contrast enhanced
- reactive oxygen species
- coronary artery bypass grafting
- mesenchymal stem cells
- subarachnoid hemorrhage
- brain injury
- fluorescence imaging