Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer.

Shangwei ZhongJi-Hak JeongChanghao HuangXueyan ChenShohreh Iravani DickinsonJasreman DhillonLi YangJun-Li Luo

Published in: Journal of experimental & clinical cancer research : CR (2021)

Our study suggests that INMT drives PCa castration resistance through detoxification of anticancer metabolites, targeting INMT or its regulator SMYD3 or/and its methylation metabolites represents an effective therapeutic avenue for CRPC treatment.

Keyphrases

ms ms
dna methylation
genome wide
transcription factor