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Revolutionizing Daptomycin Dosing: A Single 7-11 Hour Sample for Pragmatic Application.

Jacopo AngeliniShuhan LiuSimone GiulianoSarah FlamminiLuca MartiniCarlo TasciniMassimo BaraldoManjunath Amit P Pai
Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
Precision daptomycin dosing faces clinical implementation barriers despite known exposure-safety concerns with the use of twice the regulatory-approved doses. We propose achieving a single 7-11 hour post-dose plasma target concentration of 30 mg/L to 43 mg/L to be a practical starting point to facilitate precision daptomycin dosing.
Keyphrases
  • methicillin resistant staphylococcus aureus
  • blood pressure
  • primary care
  • healthcare
  • transcription factor
  • quality improvement
  • study protocol