Transcutaneous auricular vagus nerve stimulation ameliorates adolescent depressive- and anxiety-like behaviors via hippocampus glycolysis and inflammation response.
Lan SunShixiang MaYun YuXiangji LiQianwen WeiLi MinPei-Jing RongPublished in: CNS neuroscience & therapeutics (2024)
taVNS is capable of ameliorating adolescent depressive- and anxiety-like behaviors by regulating plenty of genes in the three brain regions. Suppressed level of inflammatory response and enhanced glycolysis manifests the dominant role of taVNS in HIP, which provides a theoretical foundation and data support for the molecular mechanism of antidepression by taVNS.
Keyphrases
- inflammatory response
- young adults
- mental health
- bipolar disorder
- sleep quality
- stress induced
- oxidative stress
- cerebral ischemia
- lipopolysaccharide induced
- electronic health record
- resting state
- white matter
- childhood cancer
- big data
- toll like receptor
- lps induced
- mouse model
- total hip arthroplasty
- cognitive impairment
- functional connectivity
- immune response
- bioinformatics analysis
- machine learning
- depressive symptoms
- gene expression
- dna methylation
- transcription factor
- brain injury
- genome wide analysis