Multifunctional TPP-PEG-biotin self-assembled nanoparticle drug delivery-based combination therapeutic approach for co-targeting of GRP78 and lysosome.

Baskaran PurushothamanJeongmin LeeSera HongJoon Myong Song

Published in: Journal of nanobiotechnology (2020)

Considering lysosome-mediated autophagy is an effective cancer cell survival mechanism, the degradation of the lysosome along with GRP78 inhibition by the Ru-1@TPP-PEG-biotin SAN combination therapy is suggested as a new co-targeting cancer treatment.

Keyphrases

drug delivery
cancer therapy
combination therapy
fluorescent probe
endoplasmic reticulum stress
living cells
drug release
papillary thyroid
cell death
oxidative stress
cell surface
squamous cell carcinoma
single molecule
young adults
energy transfer