Unfavorable outcomes to second-line tuberculosis therapy among HIV-infected versus HIV-uninfected patients in sub-Saharan Africa: A systematic review and meta-analysis.
Dumessa EdessaMekonnen SisayYadeta DessiePublished in: PloS one (2020)
We found a higher risk of unfavorable treatment outcome in drug-resistant tuberculosis patients with death highly worsening in HIV-infected than in those HIV-uninfected patients. The risks for the unfavorable outcomes were significantly higher in mixed-age patients and in the eastern region of sub-Saharan Africa. Therefore, special strategies that reduce the risks of death should be discovered and implemented for HIV and drug-resistant tuberculosis co-infected patients on second-line tuberculosis therapy with optimal integration of the two programs in the eastern region of sub-Saharan Africa.
Keyphrases
- hiv infected
- drug resistant
- antiretroviral therapy
- hiv aids
- ejection fraction
- human immunodeficiency virus
- mycobacterium tuberculosis
- multidrug resistant
- newly diagnosed
- hiv positive
- hepatitis c virus
- acinetobacter baumannii
- prognostic factors
- public health
- adipose tissue
- type diabetes
- south africa
- metabolic syndrome
- patient reported outcomes
- climate change
- bone marrow
- risk assessment
- patient reported