Albuminuria Is Associated with Endothelial Dysfunction and Elevated Plasma Endothelin-1 in Sickle Cell Anemia.
Kenneth I AtagaVimal K DerebailMelissa CaugheyLaila ElsherifJessica H ShenSusan K JonesPoulami MaitraDavid M PollockJianwen CaiDavid R ArcherAlan L HinderliterPublished in: PloS one (2016)
This study provides more definitive evidence for the association of albuminuria with endothelial dysfunction in SCD. Elevated circulating levels of ET-1 may contribute to SCD-related glomerulopathy by mediating endothelial dysfunction.
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