Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway.
Anna KowalczukNabila BourebabaKatarzyna Kornicka-GarbowskaEliza TurlejKrzysztof MaryczLynda BourebabaPublished in: Cell communication and signaling : CCS (2021)
Overall, the present investigation demonstrates that calystegines from Hyoscyamus albus provide cytoprotection to the HepG2 cells against insulin/glucose induced insulin resistance and apoptosis due to the regulation of SIRT1/Foxo1/G6PC/mTOR and NF-κB/JNK/TLR4 signaling pathways. Video Abstract.
Keyphrases
- signaling pathway
- oxidative stress
- diabetic rats
- pi k akt
- induced apoptosis
- insulin resistance
- high glucose
- cell cycle arrest
- type diabetes
- cell death
- epithelial mesenchymal transition
- immune response
- ischemia reperfusion injury
- adipose tissue
- lps induced
- nuclear factor
- inflammatory response
- drug induced
- endoplasmic reticulum stress
- cell proliferation
- toll like receptor
- metabolic syndrome
- endothelial cells
- blood pressure
- skeletal muscle
- polycystic ovary syndrome