Homocysteine and small vessel stroke: A mendelian randomization analysis.
Susanna C LarssonMatthew TraylorHugh S MarkusPublished in: Annals of neurology (2019)
These findings suggest that any effect of homocysteine-lowering treatment in preventing stroke will be confined to the SVS subtype. Whether genetic variants at or near the MTHFR and MUT genes influence SVS risk through pathways other than homocysteine levels and downstream effects require further investigation. Ann Neurol 2019;85:495-501.