Antifungal potential, mechanism of action, and toxicity of 1,4-naphthoquinone derivatives.
Juan Diego Ribeiro de AlmeidaRaissa Sayumy Kataki FonsecaNaira Sulany Oliveira de SousaAna Cláudia Alves CortezEmerson Silva LimaJuliana Gomes de Souza OliveiraÉrica Simplício de SouzaHagen FrickmannJoão Vicente Braga de SouzaPublished in: European journal of microbiology & immunology (2024)
The findings indicate that primary antifungal mechanism of 2,3-DBNQ might involve disrupting fungal membrane permeability, which leads to increased nucleotide leakage. This insight underscores the need for further research to enhance the selectivity and safety of naphthoquinones for potential therapeutic applications.