Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines.

Marcelle D PerrettiYaiza Pérez-PérezKevin Soler-CarracedoEndika Martín-EncinasConcepcion Alonso Jimena Scoccia Romen Carrillo

Published in: Chemical communications (Cambridge, England) (2022)

Dynamic nucleophilic aromatic substitution of tetrazines (S N Tz) has been employed to build theranostic prodrugs that are activated by hydrogen sulfide. H 2 S is typically found in high concentrations in some kinds of cancer cells and it is able to trigger the disassembly of tetrazine prodrugs. In such a way, a dual release of drugs and/or fluorescent compounds can be selectively triggered.

Keyphrases

photodynamic therapy
fluorescence imaging
quantum dots
living cells
iron oxide
label free