ERAP-1 and ERAP-2 variants in Liver injury following COVID-19 mRNA Vaccination: A US Multicenter Study.
Robert J FontanaYi Ju LiYi Ju LiDavid E KleinerJiezhun GuHersh ShroffLisa B Van WagnerPaul B Watkinsnull nullPublished in: The American journal of gastroenterology (2024)
Acute liver injury may arise within 8 weeks of COVID-19 mRNA vaccination that is generally mild and self-limited in most patients. The absence of an association with the AIH HLA alleles combined with the significant ERAP-2 and ERAP-1 Hap6 haplotype associations implicate a unique but very rare host immune response to vaccine derived antigens in the pathogenesis of COVID-19 vaccine hepatotoxicity.
Keyphrases
- liver injury
- drug induced
- coronavirus disease
- sars cov
- end stage renal disease
- ejection fraction
- chronic kidney disease
- respiratory syndrome coronavirus
- binding protein
- peritoneal dialysis
- prognostic factors
- copy number
- liver failure
- gestational age
- acute respiratory distress syndrome
- preterm birth
- extracorporeal membrane oxygenation
- patient reported