Prevalence and Clinical Implications of Mismatch Repair-Proficient Colorectal Cancer in Patients With Lynch Syndrome.
Megha RanganathanRosalba E SaccaMagan TrottierAnna MaioYelena M KemelErin Salo-MullenAmanda CatchingsSarah KaneChiyun WangVignesh RavichandranRyan PtashkinNikita MehtaJulio Garcia-AguilarMartin R WeiserMark T A DonoghueMichael F BergerDiana L MandelkerMichael F WalshMaria Isabel CarloYing L LiuAndrea CercekRona YaegerLeonard B SaltzNeil H SegalRobin B MendelsohnArnold J MarkowitzKenneth OffitJinru ShiaZsofia K StadlerAlicia J LathamPublished in: JCO precision oncology (2023)
variants. MMR-P CRC was later onset and more commonly metastatic compared with MMR-D CRC. Confirmation of tumor MMR/MSI status is critical for patient management and familial risk estimation.