Pharmacokinetics and pharmacodynamics of high-dose isoniazid for the treatment of rifampicin- or multidrug-resistant tuberculosis in Indonesia.
Vycke YunivitaFajri GafarPrayudi SantosoLidya ChaidirArto Y SoerotoTriana N MeirinaLindsey Te BrakeDick MenziesRob E AarnoutseRovina RuslamiPublished in: The Journal of antimicrobial chemotherapy (2024)
Isoniazid exposures below targets were observed in most patients, and certain risk groups for low isoniazid exposures may require dose adjustment. The effect of low isoniazid exposures on delayed culture conversion deserves attention.
Keyphrases
- mycobacterium tuberculosis
- air pollution
- multidrug resistant
- high dose
- pulmonary tuberculosis
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- low dose
- prognostic factors
- drug resistant
- stem cell transplantation
- escherichia coli
- emergency department
- patient reported outcomes
- cystic fibrosis
- hiv aids
- electronic health record
- replacement therapy