Characterization of CD4+ T cell subsets and HIV susceptibility in the inner and outer foreskin of Ugandan men.

Ronald Moses GaliwangoSergey YegorovVineet JoagJessica ProdgerKamnoosh ShahabiSanja HuibnerEnoch MuyanjaBrian Roy KabuubiAnnmarie NamuniinaAnnet NalutaayaAloysius SsemagandaFredrick LutwamaPaul Kato KitandweAnnet NanvubyaJuliet MpendoBernard BagayaNoah KiwanukaRupert Kaul

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)

There was marked heterogeneity in CD4+ T cell populations and immune milieu between inner and outer foreskin tissues. Despite higher per-cell viral entry into CD4+ T cells from the outer foreskin, the higher target cell density and enriched pro-inflammatory cytokines of the inner foreskin suggest that this may be a preferential site for HIV acquisition.

Keyphrases

single cell
antiretroviral therapy
hiv infected
hiv positive
human immunodeficiency virus
hiv testing
hepatitis c virus
cell therapy
hiv aids
sars cov
gene expression
anti inflammatory
nk cells