Atheroprotective and hepatoprotective effects of trans-chalcone through modification of eNOS/AMPK/KLF-2 pathway and regulation of COX-2, Ang-II, and PDGF mRNA expression in NMRI mice fed HCD.

Mahsa Ale-EbrahimRaziyeh RahmaniKousar FaryabiNiloofar MohammadifarPejman MortazaviLeyla Karkhaneh

Published in: Molecular biology reports (2022)

Our findings propose that the atheroprotective and hepatoprotective effects of trans-chalcone may be attributed to the activation of the eNOS/AMPK/KLF-2 pathway and down-regulation of Ang-II, PDFG, and COX-2 genes, respectively.

Keyphrases

angiotensin ii
skeletal muscle
nitric oxide synthase
pi k akt
endothelial cells
transcription factor
protein kinase
vascular smooth muscle cells
high fat diet induced
type diabetes
gene expression
adipose tissue
wild type
genome wide analysis