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Suramin increases cartilage proteoglycan accumulation in vitro and protects against joint damage triggered by papain injection in mouse knees in vivo.

Laura-An GunsSilvia MonteagudoMaryna KvasnytsiaGreet KerckhofsJennifer VandoorenGhislain OpdenakkerRik Ju LoriesFrédéric Cailotto
Published in: RMD open (2017)
Suramin prevented loss of articular cartilage in a mouse model of cartilage damage. The effects appear to be mediated by a functional increase of TIMP3 and a subsequent decrease in the activity of catabolic enzymes. Thus, suramin repositioning could be considered to prevent progressive cartilage damage and avoid evolution toward osteoarthritis.
Keyphrases
  • oxidative stress
  • mouse model
  • extracellular matrix
  • multiple sclerosis
  • knee osteoarthritis