MRI-guided focused ultrasound blood-brain barrier opening increases drug delivery and efficacy in a diffuse midline glioma mouse model.

Payton MartinezGenna NaultJenna SteinerMichael F WempeAngela PierceBreauna BruntMathew SladeJane J SongAndrew MonginKang-Ho SongNicholas EllensNatalie SerkovaAdam L GreenMark Andrew Borden

Published in: Neuro-oncology advances (2023)

Our study demonstrates that FUS-mediated BBB disruption can increase the delivery of panobinostat to an orthotopic DMG tumor, providing a strong therapeutic effect and increased survival.

Keyphrases

blood brain barrier
drug delivery
mouse model
cerebral ischemia
magnetic resonance imaging
low grade
contrast enhanced
histone deacetylase
free survival
subarachnoid hemorrhage
drug release