Dynamic Interleukin-1 Receptor Type 1 Signaling Mediates Microglia-Vasculature Interactions Following Repeated Systemic LPS.

Daniel P Nemeth Xiaoyu LiuDaniel B McKimDamon J DiSabatoBraedan OliverAnu HerdAsish KattaChristina E NegrayJames FloydSamantha McGovernPaige S PrudenFeiyang Zhutang Maria SmirnovaJonathan P GodboutJohn SheridanNing Quan

Published in: Journal of inflammation research (2022)

Here, we have identified cell type-specific IL-1R1 mediated mechanisms, which may contribute to the neuroprotection observed in LPS preconditioning. These findings identify key cellular and molecular contributors in LPS-induced neuroprotection.

Keyphrases

inflammatory response
lps induced
cerebral ischemia
brain injury
subarachnoid hemorrhage
blood brain barrier
ischemia reperfusion injury
single molecule
binding protein
spinal cord injury
drug induced