Plxnd1-mediated mechanosensing of blood flow controls the caliber of the Dorsal Aorta via the transcription factor Klf2.
Jia HeAdriana BlazeskiUthayanan NilanthiJavier MenéndezSamuel C PiraniDaniel S LevicMichel BagnatManvendra K SinghJosé G RayaGuillermo García-CardeñaJesús Torres-VázquezPublished in: bioRxiv : the preprint server for biology (2024)
Plexin-D1 mechanosensing of blood flow tunes the caliber of the Dorsal Aorta (DA)The DA widens without raising endothelial cell numbers, which can change separate from the caliberThe Kruppel-like transcription factor 2 (KLF2) is a key Plexin-D1 mechano-effector during developmentKLF2 increases endothelial cell size to expand the DA caliber.