Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment.
Breton M AskenLawren VandeVredeJulio C RojasCorrina FonsecaAdam M StaffaroniFanny M ElahiCutter A LindberghAlexandra C AppleMichelle YouSophia Weiner-LightNivetha BrathabanNicole FernandesAdam L BoxerBruce L MillerHowie J RosenJoel H KramerKaitlin B CasalettoPublished in: Journal of the International Neuropsychological Society : JINS (2021)
Plasma GFAP may be more sensitive to white matter and cognitive changes than plasma NfL. Biomarkers reflecting astroglial pathophysiology may capture complex dynamics of aging and neurodegenerative disease.