Gene-environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution.

Amin ZiaeiAmy M LaveryXiaorong Ma ShaoCameron AdamsT Charles CasperJohn RoseMeghan CandeeBianca Weinstock-GuttmanGreg AaenYolanda HarrisJennifer GravesLeslie BensonMark GormanMary R RenselSoe MarTim LotzeBenjamin GreenbergTanuja ChitinisJanace HartAmy T WaldmanLisa F BarcellosEmmanuelle Waubant

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2022)

GG genotype. Identifying gene-environment interactions may provide mechanistic insight of biological processes at play in MS susceptibility. Our work suggests a possible role of APCs for county-level ozone-induced POMS risk.

Keyphrases

multiple sclerosis
particulate matter
copy number
genome wide
hydrogen peroxide
genome wide identification
heavy metals
mass spectrometry
high glucose
ms ms
diabetic rats
air pollution
white matter
endothelial cells
nitric oxide
oxidative stress
climate change
young adults