Aspergillus fumigatus cytochrome c impacts conidial survival during sterilizing immunity.
Matthew R JamesMariano A AufieroElisa M VeselySourabh DhingraKo-Wei LiuTobias M HohlRobert A CramerPublished in: bioRxiv : the preprint server for biology (2023)
as a critical priority fungal pathogen. Our research identifies an important aspect of fungal biology that impacts susceptibility to leukocyte killing. Furthering our understanding of mechanisms that mediate the outcome of fungal-leukocyte interactions will increase our understanding of both the underlying fungal biology governing cell death and innate immune evasion strategies utilized during mammalian infection pathogenesis. Consequently, our studies are a critical step toward leveraging these mechanisms for novel therapeutic advances.