MicroRNA profiling of ovarian granulosa cell tumours reveals novel diagnostic and prognostic markers.
Wei-Tzu ChengRoseanne RosarioAnita MuthukaruppanMichelle K WilsonKathryn PaynePeter C FongAndrew N ShellingCherie BlenkironPublished in: Clinical epigenetics (2017)
This study is the first to report on global miRNA expression profiles of human ovarian GCTs using FFPE tumour samples. We have validated six miRNAs as novel markers for subtype classification in GCTs with low levels of miR-138-5p correlating with early tumour stage. Low miR-184 abundance was correlated with tumour recurrence in early stage adult-GCT patients as a candidate predictive biomarker. Further studies are now needed to confirm the clinical utility of these miRNAs as diagnostic and recurrence markers, and understand their possible roles in the pathogenesis of GCTs.
Keyphrases
- early stage
- end stage renal disease
- single cell
- endothelial cells
- cell proliferation
- ejection fraction
- newly diagnosed
- chronic kidney disease
- long non coding rna
- machine learning
- prognostic factors
- peritoneal dialysis
- free survival
- cell therapy
- type diabetes
- patient reported outcomes
- lymph node
- neoadjuvant chemotherapy
- childhood cancer